Best Ergonomic Mouse For Large Hands 2022 – No Strain, No Pain

Are you sick of compromising on mouse sizes since not every company has a mouse that fits your needs?

Finding the appropriate computer mouse for your hand size may be difficult. But fear not, since this article will provide you with just what you require: a guide to purchasing the Best Ergonomic Mouse for your Large Hands!

Selecting a mouse with a reasonable collection of features, outstanding performance, and ease of use is the ideal decision for your hands to improve your gaming and long-term working experience on a computer.

Best Ergonomic Mouse for Large Hands 2022 – Top 10 Brands

I’ve found and thoroughly studied ten mice that I believe would be ideal for your needs. These include:

Best Ergonomic Mouse for Large Hands – Reviews, Pros, & Cons

You will find each of the above-mentioned mice described in detail, along with its pros and cons, so that you can make an educated and well-informed buying decision.


Logitech M570

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1. Logitech M570 Wireless Trackball Mous


  • Adjustable DPI
  • 18 Months Battery Life
  • Easy-to-reach Back/Forward Buttons
  • Precise Cursor Control

“This product has an almost perfect 4.5/5 star rating on Amazon. ” This itself is a massive plus in its favor.

The Logitech M570 is a must-have for anyone who uses a computer on a regular basis, especially those who have large hands. The firm refers to it as a wireless trackball because, rather than moving your arm as you would with a traditional mouse you roll the trackball around with your thumb to move your mouse around the screen. Connect the unifying receiver to a USB port and turn on the trackball to complete the connection. That’s it. Start working right away!

One of the finest aspects of the M570 is its wireless connectivity. It can operate up to 30 feet away from the PC. Furthermore, because the tracking sensor is integrated into the mouse, it may be used on almost any surface. The mouse also has a long battery life and is lightweight. According to Logitech, a single AA battery may last up to 18 months.

The ergonomics of the mouse are another excellent feature. Its shape allows your hand to rest in a more natural posture, relieving wrist strain after long hours of use. The rubber grips on the button secure it to the surface it is used on, preventing inadvertent movement. Furthermore, it features normal left and right-click buttons and a scroll wheel on top, as well as easy access to forward and backward keys that can be customized using Logitech software.

It comes with adjustable sensitivity of 1200 DPI. You can set it according to your preference in the range of 400-1200 DPI. I must mention here that it offers quite good precision and tracking.

What we like
  • Works with Windows and Mac.
  • Right out of the box, the trackball is quite smooth.
  • Adjustable sensitivity settings from 400 DPI – 1200 DPI
  • Enables you to have a smaller desk space
What we don’t like
  • Is not designed for left-hand users.

It is a smooth, long-lasting, and comfortable wireless mouse that performs wonderfully while being quite inexpensive, making it the best contender for the Best Mouse for Large Hands list.


Logitech MX Master 3

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2. Logitech MX Master 3


  • DPI 4000
  • App-specific customizations
  • Connect to 3 Computers
  • Comfort shape and intuitive controls
  • 1 year limited hardware warranty

This mouse comes with a 4-foot micro USB charging cable, Logitech’s well-known unified receiver dongle, which can function with up to six devices at once, and the mouse itself. The mouse is bronze and black in color, with a matte and rubbery surface.

There are also the standard left and right buttons, an electromagnetic scroll wheel with magnets in the center that give resistance at particular points, and a shift mode that allows you to switch between ratchet and free-spin scrolling.

A power slider, a connect button, and a Logitech Dark Field sensor that works even on glass are located on the bottom of the mouse, while a micro USB charging port is located on the front of the mouse. The MX Master is a dual connectivity mouse, which means you can connect to the device via the USB Dongle or by Bluetooth utilizing the mouse to connect to three separate devices using the selecting button on the bottom of the mouse.

The horizontal scroll wheel was reintroduced into MX Master 3 from an earlier edition. Moreover, Another improvement in the Master MX 3 is the USB Type-C charging capabilities, which allows the mouse to last up to three hours on a one-minute charge and 70 days on a full charge. Additionally, it is a robust mouse with a great build quality and a shape that allows for a mature grasp while also contributing to the worth of this mouse.

More importantly, it has an ergonomic shape and is particularly suited to people that have large hands. Moreover, it comes with a 4000 DPI offering great precision in tracking.

What we like
  • A sensor with precision and accuracy of 4000 DPI
  • A one-year warranty is included.
  • Connectivity is available via both wired and cordless means.
  • It works across up to three devices and even different operating systems
  • Highly Ergonomic Shape
What we don’t like
  • It lacks texture

This device has been built for long-hour employees, and it has the benefits of optimum hand positioning for prolonged working hours, as well as long-lasting battery quality with a maximum DPI of 4000 DPI, all of which contribute to its inclusion on the list of Best Mouse for Large Hands. I must mention here that it is also one of the best mice for graphic design.


AUTLEY Ergonomic Mouse

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3. AUTLEY Ergonomic Mouse


  • DPI 800/1200/1600
  • Better for Large Hands
  • Unique Ergonomic Design
  • Easy to Use
  • 1-Year Replacement Service

In comparison to a standard mouse, this ergonomic mouse from Autley snugly fits your palm, keeping your hand and arm in a more natural posture and alleviating pain and suffering.

With dimensions of 4.84 x 3.54 x 2.87 inches, this 116 grams weighing mouse is made suitable for Large and/or Medium hands.

Sorry people with small hands, this is not meant for you.

The Autley Ergonomic wireless mouse comes with a 2.4GHz USB receiver, a micro-USB charging cable as well as a customer service card and user manual. An on/off button is located on the bottom of the mouse, allowing the user to turn the mouse on and off, as well as an LED adjustment button that enables the user to choose between accent light on or no light for the back of the mouse.

AUTLEY Ergonomic Mouse

Furthermore, this ergonomic mouse has a built-in 400mAh battery capacity, which lasts for 15 to 25 days if used moderately after a full charge, which takes up to 2 hours.

Not to mention that the mouse functions even when charging.

An interesting feature of this mouse is that it goes into sleep mode with reduced power consumption after a few minutes of inactivity and can be woken up with a click of either the right or left hand. Furthermore, as compared to a normal mouse, the Autley ergonomic mouse includes soft-click right and left buttons that are not loud. This makes it a great option for people who like to work in silence or even those that work at night.

For a better grip, the base of the mouse is equipped with Teflon pads that easily lasts for years.

What we like
  • Is compatible with Windows, Linux, & Mac.
  • Adjustable built-in DPI of 800, 1200, and 1600
  • 1-year warranty with lifetime technical support
  • Has a 2.5G wireless connection
  • Built-in rechargeable Li-Battery
What we don’t like
  • Does not have an ambidextrous design.
  • Non-programmable buttons
  • Not designed for gaming purposes.

Autley Ergonomic Wireless Mouse is quite inexpensive and has a good build quality, with a length of 4.84 inches and a height of 2.87 inches with an adjustable selection range up to 1600 DPI, making it the perfect match for the finest ergonomic mouse appropriate for large hands.


Anker 2.4G Wireless Vertical

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4. Anker 2.4G Wireless Vertical Ergonomic Optical Mouse


  • Max 1600 DPI
  • 6 Buttons
  • Power saving mode
  • Multi-device connect
  • 2.4G USB receiver

Beginning with low-cost, high-quality equipment and ending with a dedication to complete user satisfaction – Anker was established with the goal of making smart living easier. It is also one of the best mice for Sketchup.

With a 2.4GHz frequency and a USB receiver, this vertical mouse weighs only 95 grams. This mouse features a modern design that is ideally suited for enhanced usefulness and comfort, measuring 3.98 x 3.23 x 3.15 in.

This mouse combines a handshake grip, which helps to relieve tension in the hand and wrist caused by certain bigger mice, with five easy-access buttons to provide you better control over your device’s system for dragging and dropping, selecting, or just casual gaming.

Moreover, The Anker mouse has next/previous buttons on the side of the mouse for ease of webpage surfing, making it a useful tool for internet surfers, gamers, and individuals who spend a lot of time at the computer.

In addition, Ankers Optical Tracking Technology outperforms traditional optical mice in terms of sensitivity, allowing for smooth, comfortable, and precise tracking on a variety of surfaces. The mouse has an interesting function where it goes into battery-saving mode after 8 minutes of inactivity and can be woken up by pushing the right or left buttons.

Another interesting feature of this mouse is that it comes with an adjustable DPI and the options available include 800, 1200, and 1600. It is capable of ensuring amazingly precise tracking.

What we like
  • Compatible with Windows, Linus, and Mac OS X
  • 3 levels of mouse sensitivity – 800, 1200, and 1600
  • Compact, wireless ergonomic design
  • Intuitively designed thumb rests and side grips
  • 30-day money-back guarantee and a hassle-free 18-month warranty.
What we don’t like
  • Isn’t ambidextrous
  • Not for professional gamers

Smoother motions, more precision, and adjustable modifications are the primary features of this mouse with ideal dimensions, making it one of the best ergonomic mouse for Large Hands.


Logitech M510

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5. Logitech M510 Wireless Computer Mouse


  • DPI 1,000
  • Comfortable Shape
  • 7 Buttons
  •  24-month battery life
  • 3-year limited hardware warranty

The mouse’s dimensions are 4.72 x 2.56 x 1.61 inches, making it a large mouse, despite its thinner midsection than other mice, making it simpler to grip and grab.

The M510’s design encourages you to have a natural posture with your hand and the shape gives your wrist a break, while the rubber grippers on the sides and four smooth plastic pads on the bottom make mouse movement and grip simpler.

It has normal left and right clicks, as well as a scroll wheel that has the ability to tilt left and right and two additional buttons on the left side. It’s a mouse that looks very much like a regular mouse whereas the buttons on the left side are easily recognizable as to which one is being pushed, by the thumb.

Although the mouse only has five customizable buttons, the tilt flexibility of the scroll wheel with the feature of being customizable, adds value and compensates for the lack of buttons.

The mouse requires two batteries to function and amazingly one pair of batteries easily lasts up to two years. Inside the battery compartment, there’s also a unified receiver portion containing the USB dongle with a 2.5GHz frequency, which can be linked to a Mac or a Windows system and utilized with the mouse.

What we like
  • Total 5 customizable buttons
  • Warranty of upto 3 years
  • Can run up to 24 hours on a full charge
  • Long-lasting battery life
  • Allows tiltable scrolling
What we don’t like
  • Is only ambidextrous if you don’t require the side thumb buttons.
  • Doesn’t come with Logitech’s DarkField Technology.

With a sensitivity of 1000 DPI and a big size, the Logitech M510 Wireless Mouse is a low-cost option among customizable cordless mice. The Logitech software makes customization simple and flexible with only a single click of a button, making it one of the best mouse for Large Hands.


SteelSeries Rival 310

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6. SteelSeries Rival 310 Gaming Mouse


  • 12,000 CPI
  • 6 Buttons
  • Durable
  • Ergonomically designed
  • RGB Lighting

The Rival 310 is a fantastic mouse with a distinctive design that weighs close to a mere 88.3 grams, which is 10 grams less than the SteelSeries Rival 300 edition, without making the mouse seem fragile.

This SteelSeries mouse has an ergonomic design with a flat back that matches the curvature of your hand and is the only style that keeps your fingers straight on the mouse buttons.

For in-depth design details of the 310, the top of the mouse is textured plastic, and the mouse elevation from the center prevents sliding. A slight inclination for the thumb is also included, with the outward-going slope assisting with mouse handling and lifting whereas the pure silicone patterned grip aids in maintaining a solid grasp on the mouse without the risk of slipping.

Perfect dimensions are essential for a mouse to be best suited for Large hands. The Steelseries Rival 310 features a grip width of around 2.4 inches from the center, a base length of about 5 inches that is more important to how you hold the mouse, and a height of about 1.7 inches with the mouse’s weight in line with the sensor.

Furthermore, the mouse includes a total of six buttons: left and right clicks, a scroll wheel, side buttons, DPI adjustment buttons, and so on where the left and right click buttons are sufficiently tensioned to avoid inadvertent clicks.

Another important feature provided by this mouse is its tracking quality. The mouse tracks pixel by pixel and immerses smoothly as expected with a CPI range starting from 100 to 12,000 with increments of 100.

Furthermore, the mouse has Split-trigger buttons that provide long-lasting sturdiness as well as a quick and steady click sensation while moving a certain distance on the mousepad results in the same precise distance on screen, with no delay, while having no effect on jitter reduction.

What we like
  • Mechanical switches with 50 million clicks
  • 12,000 CPI and 350 IPS optical sensor
  • Ultra-low jitter and accurate precision
  • Guarantees speed and balance with all grip types
  • Allows you to create your own gradients for its RGB lighting
What we don’t like
  • Doesn’t offer spinouts

This mouse is one of the best ergonomic mouse developed for Large Hands, including an exclusive split-trigger mouse button design with the world’s first real 1 to 1 esports sensor, as well as exceptional comfort and grip and precise tracking from 100 to 3,500 CPI.


Razer Naga X

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7. Razer Naga X Wired MMO Gaming Mouse


  • DPI 18,000
  • 16 Programmable Buttons
  • Chroma RGB Lighting
  • Ergonomic design
  • 5G Optical Sensor

The newest addition to the long line of the Naga family of mice is the Razer Naga X Wireless MMO Gaming Mouse which is the most affordable MMO gaming mouse in the Naga series, as well as the 12th edition of the ever-popular MMO mouse with several upgrades over previous models.

The Naga X has a lightweight construction for its size due to the lack of a substitute for the thumb side grip that a few previous naga mice have. It also features a pinky and ring finger placement space on the right side of the mouse, as well as 12 buttons to the left, with the 2,5,8, and 11 numbered keys offset, which assists in muscle memory formation when striking these buttons when working or playing.

Furthermore, these buttons may be utilized to map out important hotkeys or macros, and the HyperShift function allows you to double your inputs with a secondary button profile that can be swapped with a single keypress via Razers software.

With 16.8 million colors and dynamic in-game lighting effects, the mouse also allows for complete RGB customization and greater immersion with the Razer Chroma RGB. In addition to that, the mouse’s ergonomic design makes every swipe seem smooth, and it comes with two grip styles: palm grip and relaxing or aggressive claw grip.

Adding on, the inbuilt Razer sensor provides 99.4 percent tracking accuracy, allowing for an advanced degree of precision by using the mouse software to establish a preset or custom surface profile.

What we like
  • Features Razer™ 5G Advanced Optical Sensor
  • Excellent onboard memory profile
  • 2nd-generation Razer Optical Mouse Switches
  • Wide range of DPI selection up to 18000 DPI
  • 16 fully customizable buttons
  • Smooth mouse movement with PTFE mouse feet.
What we don’t like
  • Doesn’t have a magnetic modular design
  • No tilt-shifting available

“Recommended for gamers with medium to large hand sizes..” Because of its lighter weight and best-in-class features such as a maximum sensitivity of 18000 DPI, tighter control and faultless execution with its optical switch technology, and an improved degree of accuracy, the Razer Naga X is one of the best ergonomic mouse for large hands that you could lay your hands on!


Logitech G604 LIGHTSPEED

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8. Logitech G604 LIGHTSPEED Wireless Gaming Mouse


  • 25,000 DPI Sensor
  • 240 hour battery life
  • 15 programmable Buttons
  • Dual connectivity
  • 2 Years Limited Hardware Warranty

The Logitech G604 Lightspeed wireless mouse is the confluence of three popular Logitech mice that have been available over the years. The G604 features an ergonomic design with grooves on the side to suit your ring and pinky finger and a fin jutting out on the left side for your thumb rest.

In the center and on both sides, it features a little rubberized, textured surface for improved grip. Another major feature that saves the mouse’s battery life, as you may have noticed, is the lack of RGB illumination.

Moreover, The mouse’s in total 15 buttons, including the scroll wheel, are all programmable. It features conventional left and right-clicks buttons, a scroll wheel that can be tilted left and right, a button below it to enable a hyper scroll followed by a connectivity button to convert to Lightspeed wireless and Bluetooth connection.

It also features DPI adjustment buttons on the top-left side of the left click, denoted by a plus and minus symbol, that let you alter the DPI with the click of a button.

In addition, there are six side buttons located just above the thumb rest and labeled G4 through G9. Because they’re right above your thumb, these macros may be customized by the user based on the program being used in order to quickly and conveniently access them via muscle memory.

In addition to that, the bottom half of the mouse has a magnetic door that can easily be removed, which is used to store the unifying USB receiver or wireless dongle when not in use, as well as a mouse battery compartment.

What we like
  • Battery life of up to 240 hours in Lightspeed mode
  • Features Logitech’s Hero 25K sensor
  • 15 fully customizable buttons
  • Maximum precision up to 25,600 DPI
  • Offers a 2-year long warranty.
  • Hyper-scroll wheel
What we don’t like
  • Is really light and lacks substance.

This Logitech mouse is 5.12 inches tall and 3.15 inches wide, with a combination of class-leading accuracy and power efficiency, as well as the most advanced sensor with precise 1:1 tracking with zero smoothings, allowing you to work or play for long periods of time with ease, making it the best ergonomic mouse for people with large hands.


Logitech MX Vertical Mouse

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9. Logitech MX Vertical Wireless Mouse


  • 4000 DPI high-precision sensor 
  • Natural Handshake Position
  • Three Ways to Connect
  •  4 months on a full charge
  • Erofomic Design

This mouse stands out from the crowd since it has Logitech’s first-ever vertical mouse in the MX Series.

The mouse’s design has left and right click buttons on the right side, as well as a scroll wheel in the center. Unfortunately, unlike its other models, this mouse does not include Logitech’s hyper scrolling function.

The mouse includes a handful of programmable buttons on the left side, while the front of the mouse has a USB-C charging connector. When it comes to the battery, one charge will last four months, while one minute of charging will provide three hours of use.

What is the feel of this mouse in your hand? The goal of vertical mice is to put you in a more natural, comfortable position which is exactly what this mouse does.

Holding this mouse puts it in a handshake position, but because it’s leaning at a 57-degree angle, it gives you exactly the right amount of lean while also requiring the majority of your hand to be in touch with the mouse, giving you superior control.

Logitech MX Vertical Wireless Mouse

The mouse’s exterior has a textured surface that is very pleasant to hold, and the 4000 DPI sensor aids in accurate cursor movement on your screen without having to move your mouse too much on the screen, resulting in less strain on your wrist.

Additionally, the top-mounted Button allows you to cycle through several speed settings while holding on to the mouse allows you to change the cursor’s speed to suit your demands.

What we like
  • Comes with a 4000 DPI sensor
  • Allows a natural handshake position
  • Reduces hand movement by 4x
  • Features Logitech Flow
What we don’t like
  • Doesn’t include a Hyper-scroll wheel

The ergonomics of the Logitech MX Vertical mouse take precedence over a wide range of features. This mouse has a unique shape that fits a variety of hand shapes and sizes, is lightweight, has excellent handling, and a wide DPI range, making it one of the best mouse models for people with large hands.


J-Tech Digital

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10. J-Tech Digital Wired Ergonomic Vertical USB Mouse


  • 600/1000/1600 DPI
  • 6 Buttons
  • Natural Handshake Position
  • Ergonomic Design
  • Optical Tracking Technology

The peculiar mouse form aids in the support and prevention of forearm twisting, which can be unpleasant at times, while also providing a handshake sensation to the user. The pressure produced by twisting your wrist is practically reduced in this handshake position.

The J-Tech mouse, which measures 5.8 x 3.7 x 3.8 inches, surpasses the competition largely in terms of compact design.  The next and back buttons are all situated in the thumb rest zone, making it easy to hit those keys with just your thumb instead of your full hand while the scroll wheel, also serving as a button, is located between the left and right clicks on the right side of the mouse.

J-Tech Digital Wired Ergonomic Vertical USB Mouse

Another cool feature besides the intuitive design of the mouse is its Scroll Longevity, which features adjustable sensitivity, that can be altered on the fly with the mouse’s DPI button.

Furthermore, its advanced high optical sensor is extremely precise for the vast majority of vocations. The mouse allows you to select from three sensor settings: 800, 1200, and 1600 DPI which guarantees better sensitivity for precise tracking on a variety of surfaces.

What we like
  • Can support up to three million clicks
  • Comes with a detachable palm rest
  • Comes with a one-year manufacturer warranty
  • Free of cost technical support for a lifetime.
  • Adjustable sensor settings (800, 1200, 1600 DPI)
  • Features customizable buttons along the thumb area.
  • Compatible with Linux, Vista 7/8 , and Windows 7/8/10, XP
What we don’t like
  • No gameplay optimization.
  • For right-handed users only

It is one of the best ergonomic vertical mouse not only because of its outstanding intuitive design but also because of its exceptional utility and affordable price, as well as an acceptable size for Large Handed individuals while also minimizing wrist torsion, allowing it to be on this list of best mice for Large Hands.

How To Choose The Right Mouse For Large Hands?

Many manufacturing firms do not consider size to be a concern, but others genuinely care about their consumers and cater to this issue in order to earn the hearts of the large-handed community.

Best Ergonomic Mouse for Large Hands

Perfect Dimensions

Great dimensions are the first thing to think about when testing and buying the right-sized mouse for your needs. For various people, different mouse sizes are comfortable and ideal but bigger ergonomic mice are generally chosen by large handers because they have greater surface areas and provide greater grip than normal mice. You should choose a mouse that is appropriate in size for your grasping requirements.

Quantity of Buttons

This is another significant factor you need to take into consideration before you buy a mouse. Excessive buttons allow you to map buttons for macros, shortcut keys, gaming keys, and so on. The greater the number of programmable buttons on a mouse, the better.

DPI Range

The DPI range of a mouse is very important to take into account when choosing a mouse. Jitter reduction is aided with a high DPI range, which allows for smoother and quicker movement with no lag and precise tracking ability. As a result, a mouse with a high DPI range is always a superior option.


If you’ve read thus far, we hope you’ll be able to choose from the best 10 mice on the market without having to worry about limited features owing to your hand size. Don’t wait any longer, get the Best Ergonomic Mouse for your Large Hands now!